{"id":487,"date":"2007-01-17T11:48:01","date_gmt":"2007-01-17T15:48:01","guid":{"rendered":"http:\/\/lunardreams.net\/ttc\/?p=487"},"modified":"2007-01-17T12:10:39","modified_gmt":"2007-01-17T16:10:39","slug":"success-rates-in-unexplained-infertility","status":"publish","type":"post","link":"http:\/\/lunardreams.net\/baby\/?p=487","title":{"rendered":"Success Rates in Unexplained Infertility"},"content":{"rendered":"<p>This study (quoted on <a href=\"http:\/\/www.wdxcyber.com\/minfert.htm\">this FAQ<\/a>) reflects what I&#8217;ve been thinking. I&#8217;ve highlighted the parts that stood out to me.<\/p>\n<div class=\"quote\">Hum Reprod 1997 Sep;12(9):1939-1944<\/p>\n<p>Cumulative pregnancy rates in couples with anovulatory infertility compared with unexplained infertility in an ovulation induction programme.<\/p>\n<p>Tadokoro N, Vollenhoven B, Clark S, Baker G, Kovacs G, Burger H, Healy D<\/p>\n<p>Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.<\/p>\n<p>Using a retrospective analysis, we compared cumulative pregnancy rates, early pregnancy failure rates and multiple pregnancy rates in couples with polycystic ovarian syndrome (PCOS) (n = 148), hypogonadotrophic or eugonadotrophic hypogonadism (n = 91) and unexplained infertility (n = 117), who were treated in an ovulation induction clinic between January 1991 and December 1995. The women were treated with either human menopausal gonadotrophin (HMG) or purified follicle stimulating hormone (FSH). <b>The cumulative pregnancy rate (derived from life-table analysis) after four ovulatory treatment cycles was 70% in the PCOS group, 74% in the hypogonadism group and 38% in the unexplained infertility group.<\/b> The cumulative pregnancy rate in the unexplained infertility group was significantly lower than the other groups (P &lt; 0.001) but there was no significant difference between PCOS and hypogonadism using the log rank test. The early pregnancy failure rate was 25% in the PCOS group, 27% in the hypogonadism group and 26% in the unexplained infertility group (chi(2) = 0.132, not significant). The multiple pregnancy rate was 20% in the PCOS group, 30% in the hypogonadism group and 17% in the unexplained infertility group (chi(2) = 2.105, not significant). Treatment of anovulatory infertility using HMG or FSH is effective irrespective of the cause. Couples with unexplained infertility are less successfully treated using HMG: correction of unexplained infertility may involve more than simple correction of possible subtle ovulatory defects.<\/div>\n<p>Basically, ovulation induction as a means of infertility treatment doesn&#8217;t work half as good for those with unexplained than those who have some form of anovulation disfunction. Which is completely logical &#8211; in most cases with those who are anovulatory your main battle is going to be ovulation, and it appears most of the time that&#8217;s all you need. But for those of us for whom that is not a problem, ovulating &#8220;more&#8221; or &#8220;better&#8221; isn&#8217;t going to make a huge difference in the end result.<\/p>\n<p>This only strengthens my opinion that we should move to IVF sooner rather than later. Sigh.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study (quoted on this FAQ) reflects what I&#8217;ve been thinking. I&#8217;ve highlighted the parts that stood out to me. Hum Reprod 1997 Sep;12(9):1939-1944 Cumulative pregnancy rates in couples with anovulatory infertility compared with unexplained infertility in an ovulation induction programme. Tadokoro N, Vollenhoven B, Clark S, Baker G, Kovacs G, Burger H, Healy D [&hellip;]<\/p>\n","protected":false},"author":71,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[16],"class_list":["post-487","post","type-post","status-publish","format-standard","hentry","tag-fertility"],"_links":{"self":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/posts\/487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/users\/71"}],"replies":[{"embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=487"}],"version-history":[{"count":0,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/posts\/487\/revisions"}],"wp:attachment":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=487"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}