{"id":1013,"date":"2008-01-25T22:50:29","date_gmt":"2008-01-26T03:50:29","guid":{"rendered":"http:\/\/lunardreams.net\/baby\/?p=1013"},"modified":"2008-01-25T23:03:45","modified_gmt":"2008-01-26T04:03:45","slug":"more-research-needed","status":"publish","type":"post","link":"http:\/\/lunardreams.net\/baby\/?p=1013","title":{"rendered":"More Research Needed"},"content":{"rendered":"

From the prescribing information for Celexa<\/a> and Zoloft<\/a>:<\/p>\n

Celexa:<\/p>\n

Nursing Mothers
\nAs has been found to occur with many other drugs, citalopram is excreted in human breast milk. There have been two reports of infants experiencing excessive somnolence, decreased feeding, and weight loss in association with breastfeeding from a citalopram-treated mother; in one case, the infant was reported to recover completely upon discontinuation of citalopram by its mother and in the second case, no follow-up information was available. The decision whether to continue or discontinue either nursing or Celexa therapy should take into account the risks of citalopram exposure for the infant and the benefits of Celexa treatment for the mother.<\/div>\n

Zoloft:<\/p>\n

Nursing Mothers\u00e2\u20ac\u201cIt is not known whether, and if so in what amount, sertraline or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when ZOLOFT is administered to a nursing woman.<\/div>\n

Well that sure doesn’t help clear things up for me. 2 reports? I mean, obviously one would hope for no negative side-effects. What what kind of risks are we looking at here? 2 out of how many?<\/p>\n

So what’s my plan: find a Lactation Consultant to, err, consult with… which I can search for online<\/a>. And then talk with the pediatrician about it. Then go from there.<\/p>\n

Added:<\/p>\n

Searching Toxnet<\/a> for citalopram gave far more information.<\/p>\n

Infants receive citalopram in breastmilk and it is detectable in low levels in the serum of some. The dosage that the infant receives and serum level achieved are probably related to the genetic metabolic capacity of the mother and infant. A few cases of minor behavioral side effects such as drowsiness or fussiness have been reported, but no adverse effects on development have been found in infants followed for up to a year.<\/div>\n
The manufacturer states that drowsiness and weight loss in breastfed infants has occurred.<\/p>\n

Uneasy sleep that reversed with dosage reduction and partial formula supplementation was probably caused by citalopram in breastmilk in a 5-month-old infant.[5]<\/p>\n

A group of 9 infants breastfed (6 exclusive, 3 received some formula beginning at 2 months) from birth to one year during maternal citalopram use had normal body weight and neurological development in all infants compared to 9 control infants whose mothers did not take citalopram.[2]<\/p>\n

Three mothers who took an average citalopram dose of 15 mg once daily breastfed their infants exclusively for 4 months and at least 50% during months 5 and 6. Their infants had 6-month weight gains that were normal according to national growth standards.[6]<\/p>\n

A study compared adverse reactions in 31 infants breastfed during maternal citalopram use to a control group of 31 breastfed infants whose mothers did not take an antidepressant. There were numerically more adverse events reported in the citalopram group (3 vs 1). However, the study found no statistical difference in the rate of adverse effects between the groups of infants and none of the side effects was serious. One mother reported infant irritability and restlessness after she began citalopram at 2 months postpartum. The side effects subsided after she stopped breastfeeding 2 weeks later.[7]<\/p>\n

In 9 breastfed (extent not stated) infants aged 3 to 42 weeks whose mothers were taking citalopram an average of 24 mg daily, no adverse reactions were noted clinically at the time of the study.[3] <\/p><\/div>\n

Interesting.<\/p>\n","protected":false},"excerpt":{"rendered":"

From the prescribing information for Celexa and Zoloft: Celexa: Nursing Mothers As has been found to occur with many other drugs, citalopram is excreted in human breast milk. There have been two reports of infants experiencing excessive somnolence, decreased feeding, and weight loss in association with breastfeeding from a citalopram-treated mother; in one case, the […]<\/p>\n","protected":false},"author":71,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[41,13,57],"class_list":["post-1013","post","type-post","status-publish","format-standard","hentry","tag-breastfeeding","tag-depression","tag-pregnant"],"_links":{"self":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/posts\/1013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/users\/71"}],"replies":[{"embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1013"}],"version-history":[{"count":0,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=\/wp\/v2\/posts\/1013\/revisions"}],"wp:attachment":[{"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1013"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1013"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/lunardreams.net\/baby\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}